Permeability of Thermally Damaged Skin: I. Immediate Influences of 60°C Scalding on Hairless Mouse Skin
نویسندگان
چکیده
منابع مشابه
Transdermal delivery of phosphorodiamidate Morpholino oligomers across hairless mouse skin.
The skin is the largest organ in the body and an obvious route for both local and systemic drug delivery. Antisense oligomers have tremendous potential as therapeutic agents for numerous diseases. The objective of this study was to investigate the influence of vehicle on the transdermal delivery of several phosphorodiamidate Morpholino oligomers (PMOs) with different sizes, lengths, base compos...
متن کاملPermeation of water contaminative phenols through hairless mouse skin.
As a means of determining the risk of absorption of water contaminative phenolic compounds through the skin, the permeat ion of a number of phenols, all on the U.S. Environmental Protection Agency ' s list of priority pollutants, through hairless mouse skin has been studied, using in vitro diffusion cell methods. Experimentally determined permeability coefficients through intact skin and stratu...
متن کاملSkin morphology of the mutant hairless USP mouse.
The morphology of the skin of the mutant hairless USP mouse was studied by histological, histochemical and immunohistochemical methods and compared to the skin of BALB/c mice. Representative sections of the dorsal skin from mice of both strains aged 18 days, and 1, 3, 6, and 8 months were studied. Sections stained with hematoxylin and eosin showed cystic formations called utricles and dermal cy...
متن کاملEffects of hormonal factors and of the hereditary character hairless on the sterols of mouse skin.
The sterol A7-cholestenol constitutes a large proportion of the total sterols of rat and mouse skin (5, 7, 18). Whereas the concentration of this sterol is not altered by such factors as diet, metabolic rate (7), and ultraviolet light (13), it decreases rapidly following the application of carcinogenic hydrocarbons to mouse skin (5). This decrease coincides with destruction of the sebaceous gla...
متن کامل[Evaluation of the permeability of corticosteroid in hairless mouse and hairless micropig skin from admixture of commercially available corticosteroid ointments and/or creams].
Yucatan hairless micropig (YHMP) skin has been shown to have histology and physiologic properties similar to human skin. To assess the relationship between the permeability of corticosteroid ointments and five types of commonly used admixtures of corticosteroid through hairless mice (HM) or YHMP skin and the clinical effects in humans, we conduct by in vitro experiments using HM and YHMP skin. ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1980
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12531096